• Value in integrity, equality, and solidarity;
  • Advance exchange in science and research;
  • Promote communication, collaboration and connection;
  • Establish platforms in developing career and probing the essence of life;
  • Reach out to community and public.

2012-01-17

Happy New Year and Happy Science!

 

1、科学的分类(Science Classification

  • 如果是绿色的或是在摆动,属于生物学的一部份;(If it’s green or it wiggles, it’s part of Biology
  • 如果发臭,是化学;(If it stinks, it’s Chemistry
  • 如果得不到结果,属于物理学。(If it doesn’t work, it belongs to Physics

 

2、实验室工作者守则(Rules for Laboratory Workers

  • 如果你不知道你在做什么,做得干净整洁点;(When you don’t know what you’re doing, do it neatly
  • 首先画个曲线,然后描出你的数据;(First draw your curves, then plot the data
  • 工作经验和损坏的仪器设备成正比;(Experience is directly proportional to the equipment ruined
  • 试验必须要可以重复——它们应当以同样的方式失败;(Experiments must be reproducible. They should all fail the same way
  • 数据记录非常重要——它们表明你一直在工作;(A record of data is essential. It indicates you have been working
  • 有疑问的时候要让它们听起来很有说服力;(In case of doubt, make it sounds convincing
  • 不要相信奇迹——要依赖它们;(Do not believe in miracles, rely on them
  • 实验室里团队协作很重要——使你有其他人可以归咎;(Teamwork is essential in the lab. It allows you to blame someone else
  • 当得不到结果时,要常常留有解释的余地。(Always leave room to add an explanation when it doesn’t work

 

3、菲内格定律、信条及座右铭(Finagle’s Law, Creed, and Motto

  • 第一定律——如果实验中有任何事情可以出错,就会出错;(First Law – If anything can go wrong with an experiments, it will
  • 第二定律——不管预期的结果如何,总会有人愿意伪造它;(Second Law – No matter what results is anticipated, there is always someone willing to fake it
  • 第三定律——不管发生什么,总会有人根据其钟爱的理论而相信它;(Third Law – No matter what occurs, there is always someone who believes it happened according to his pet theory
  • 第四定律——不管是什么样的结果,总会有人急切地想去胡乱解释它;(Fourth Law – No matter what the result, there is always someone eager to misinterpret it
  • 信条——科学是真理。不要被事实误导;(Creed – Science is truth. Don’t be misled by facts
  • 座右铭——微笑;明天会更糟。(Motto – Smile; tomorrow it will be worse

(Translated by Jian Liu)

    2011-10-17

    [PSF series talk/费城科学论坛系列讲座] Circadian Rhythms and Physical Fitness

    Circadian Rhythms are regulated by cell-autonomous molecular feedback loops, termed circadian clock that modulates the daily physiological processes to optimize the maximal physiological fitness. Many important aspects of processes, for example, daily rest/activity cycle, blood pressure, metabolic rates and many more, are known to be under the regulation of circadian clocks. Dr. Yang will tell us not only how circadian clock generally works, but also how PPARgamma, a transcription factor, is able to regulate a critical circadian clock transcription factor BMAL1 and regulate behavioral and metabolic circadian rhythms. Come join us and see how circadian clock is also regulating the biology you are working on.

     

    Title: PPARγ Is a Master Regulator of Circadian Rhythms of Behavior and Metabolism
    Speaker: Dr. Guangrui Yang, Department of Pharmacology, University of Pennsylvania
    Time: 10/26/2011, Wednesday, 6:00pm-7:30pm
    Venue: Clinical Research Building (CRB) room 302
    Drink and Snack will be provided at the seminar.

    2011-10-13

    [PSF series talk/费城科学论坛系列讲座] 名家讲坛: 于丹《感悟东方智慧》& 程凯《通畅身体母亲河》

    We are delighted to announce that two Chinese scholars, Dan Yu and Kai Chen, will give us two lectures at the Chemistry Building Room 102, UPenn on Nov 12, Saturday. The lectures will be given in Chinese. Pre-registration is required. Please refer to the attached flyer.

    文化中国 - 名家讲坛


    于丹: 著名中国古典文化学者, 讲标题 感悟方智慧

    :著名中医医学博士, 讲标题 身体母


    地点 (Location): University of Pennsylvania Chemistry Building 102

    231 South 34th St. Philadelphia PA 19104

    时间 (Time): 1112 星期六

    10:00 AM -12:00 PM (于丹)

    2:00 PM - 4:00 PM ()

    : 美国洲文化中心

    http://www.asiancc.net

    协办: 城科学论坛

    http://www.newpsf.org

    特别鸣谢: 中国海外交流

    座免工作言中文需网上注册

    https://docs.google.com/a/acngusa.com/spreadsheet/viewform?formkey=dEVMNEJ1ZUJ1YnUzZzlwZFdJYmhHb3c6MQ

    查询电话: 212-679-8833 ext 118


    2011-07-17

    [PSF series talk/费城科学论坛系列讲座] Merck Director 分享职场经验及Q&A_July 23rd, Saturday 2-5pm

    titles.gif


    Career Development Association at Penn
    Philadelphia Science Forum
    Society for Clinical and Biomedical Research



    Individual's Growth and
    Success within a Team


    Zak Huang, MD
    Director, Worldwide Regulatory Affairs
    Merck & Co., Inc


    Saturday, July 23rd, 2011 2 - 5pm
    Clinic Research Building 302
    415 Curie Blvd

    How do you improve yourself?
    Why should others like you? Respect you?
    How do you interact with your team?
    How do you lead and influence others?



    If interested in attending this event, please RSVP by clicking here,
    or to careerdevassoc@gmail.com Space is limited.
    Please include school / program, your graduation year and
    your interested fields or industries.

    Zak huang MD.jpg




    Dr. Zak Huang received medical training from Nanjing Medical College, and practiced medicine for 7 years in Jiangsu Province Hospital, Nanjing, China. He has acquired a broad range of experience in pharmaceutical, biologics and medical device development, both in clinical research and regulatory affairs. He designed and conducted clinical trials at University of Minnesota, Guidant Corporation (now Boston Scientific) and Eli Lily & Co. His career in regulatory affairs started at Guidant in 2002, providing regulatory leadership on Class III medical device programs. In 2004, Dr. Huang joined Merck & Co., Inc. as Director of Worldwide Regulatory Affairs, leading global regulatory teams. He has been in charge of regulatory strategy for development programs of pharmaceutical and biologics products, and alignment between program development and regulatory strategy. Externally, he has been the company representative on specific products, liaising with regulatory authorities, especially, the U.S. FDA, for all regulatory issues. At Merck, he has received "Award of Excellence", "Division Award" or "Special Achievement Award" 11 times, with 4 awards directly related to special contributions to China-related activities.

    2011-04-16

    [PSF series talk/费城科学论坛系列讲座] How is the nucleotide coding sequence related to a posttranslational modification?

    It's our great honor to invite Dr Fangliang Zhang from the University of Pennsylvania School of Veterinary to give a PSF series talk on "How is the nucleotide coding sequence related to a posttranslational modification?". During the talk Dr. Zhang will also share with us his experience on looking for a tenure track position in the US.

     

    Speaker: Fangliang Zhang, PhD, University of Pennsylvania School of Veterinary

    Time: April 27 Wednesday 6:00-7:30pm

    Venue: Clinical Research Building (CRB) room 302

     

    Abstract:  Actin is the major component of microfilament cytoskeleton. Nonmuscle cells contact two actin isoform beta and gamma actin, which are extremely similar in amino acids. Beta-actin is found to have N-terminal arginylation, which regulates its function. However gamma-actin was never found to be arginylated on the same site in vivo. To investigate this puzzle, we check the metabolic fate of artificially arginylated gamma-actin and found it is highly unstable and selectively ubiquitinated and degraded in vivo compared to the beta-actin. This instability was regulated by the differences in the nucleotide coding sequence between the two actin isoforms, which conferred different translation rates. Gamma-actin was translated more slowly than Beta-actin, and this slower processing resulted in the exposure of a normally hidden lysine residue for ubiquitination, leading to the preferential degradation of gamma-actin upon arginylation. This is the first demonstration that the nucleotide coding sequence can be utilized to regulate protein posttranslational state.

    2011-03-26

    [PSF series talk/费城科学论坛系列讲座] The role of c-Abl tyrosine kinase in T cell actin responses

    You are cordially invited to the next PSF series talk by Dr. Yanping Huang from the Children Hospital of Philadelphia.

    Cells are not bags of soup largely because actin skeleton plays huge roles in organizing the subcellular structures and helping cargo transporting etc during many cellular processes, facts that deserve much more attention in biological/clinical researches. Dr. Huang will introduce to us the actin biology. Most importantly, she will talk on her new finding on how T-cell actin responses are regulated by T-cell signaling pathway through the tyrosine kinase c-Abl.

    Brief introduction:

    Virtually every aspect of T lymphocyte function, including differentiation, migration and effector function depends on regulated reorganization of the actin cytoskeleton. Dysregulation of these events is associated with immunodeficiency and autoimmunity, as well as leukemia and lymphoma. As in other cell types, T cell actin responses are controlled by the coordinated action of multiple actin regulatory proteins, which function downstream of a complex network of kinases and other signaling molecules. The Abl nonreceptor tyrosine kinases, which include c-Abl and Abl-related gene (Arg), are well known for their relationships with leukemia. c-Abl and Arg play an important role in regulating actin responses in other cell types, but their role in T cells are poorly understood. We have found that c-Abl is a key player in the T cell signaling cascade, leading to actin reorganization during T cell activation (Blood. 2008, 112 (1): 111-9). Our current studies focus on identifying Abl family kinase substrates in T cells, and determining how Abl family kinases and their substrates cooperate to regulate T cell actin remodeling.

    Please join the talk on Friday (April 1) from 4:30-6:30pm at the Clinical Research Building room 302. Refreshment will be served.

    2011-03-23

    [PSF实用讲座系列] 2010 个人及家庭报税讲座 Mar 28 6PM @DRL A6

    Time: March 28 (Monday) 6:00-7:30 PM (open to all)

    Location: Room A6, David Rittenhouse Laboratory, 33rd and Walnut Streets

    2010 个人及家庭报税讲座

    一年一度的报税季节已经来了。美国是一个高收入高税收的国家, 家庭“税”的管理极其重要。政府提供了许多有税上好处的政策, 但不同的人可以享受的税的优惠也不同。目前的优惠政策大多有一定的有效期。潜在的税的问题不可忽视。税法是美国最繁杂的法律之一,尤其很多中国过来的留学生更是对每年的1040表知之甚少。常见问题有:

    • What’s Filing Status for individual tax?
    • What’s AGI and Taxable Income?
    • What’s Marginal tax rate and Effective tax rate?
    • What’s Social Security tax, Medicare tax and Self-employment tax?
    • What’s Schedule A, B, C, D?
    • What’s Capital Gain and Dividends tax?
    • What’s Estate and Gift tax?
    • What’s AMT?
    • F1, J1, OPT, H1B, FICA taxes?

    你想知道怎么去填1040(NR)表,你想知道今年税法有什么新的改变,你想知道今年政府给了多少credit,你想知道F,J,Q,M签证,CPT,OPT,H1B牵涉的税务问题吗?你想知道F1学生能否拿回所有的联邦税以及对申请绿卡的影响?填错的税表怎样去修正?所有这些问题都会由专家给你解答。 (信息量很大,请带好纸笔。)