Dr. Kevin Yu will give a talk on free radicals in normal physiological functions and human cardiovascular diseases at BRB II/III Rm 1101 7:00 pm.
Free radicals mainly referred to reactive oxygen species (ROS) and reactive nitrogen species (RNS) are products of normal cellular metabolism. They are well recognized for playing a dual role in our bodies. The beneficial effects of ROS/RNS occurred at low concentration include (1) defence against infectious agents, (2) being second messengers of cellular signaling pathways, and (3) regulation of cell proliferation and differentiation. The deleterious effects of the ROS/RNS occurred at excessive level are related to most of human diseases and aging. The ROS induced oxidative stress in cardiovascular system has been linked with various cardiovascular diseases such as atherosclerosis, ischemic heart disease, hypertension, cardiomyopathies, cardiac hypertrophy and congestive heart failure. Some details are discussed for the oxidation of the Low-density lipoprotein (LDL) by free radicals as an important step in the development of the atherosclerosis.
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