The first Philadelphia Science Forum talk in 2010 will be held at BRB2/3 Room 801 6-7:30pm Friday (Jan. 29).
Title: CREB deficiency suppresses the development of epilepsy
Speaker: Xinjian Zhu, PhD (the Children’s Hospital of Philadelphia)
Abstract: Epilepsy is a disease of recurrent seizures that can develop after brain insults. To prevent the morbidity and mortality associated with the epilepsy we need to better understand the molecular and cellular mechanisms that contribute to the development of epilepsy. Several lines of evidence suggest that cAMP response element-binding protein (CREB) might be involved in the development of epilepsy. In this study, the chemoconvulsant pilocarpine and kindling model were used to investigate the role of CREB in the development of epilepsy. Our results implicated that deficiency of CREB suppressed the development of epilepsy in the pilocarpine and the kindling model. Blocking CREB activity following a brain insult may suppress the development of epilepsy.
Snack and beverage will be served. For event details, future event announcement, or subscription to the discussion group, please visit www.newPSF.org.
Photos here by Xiaoyu.
Title: CREB deficiency suppresses the development of epilepsy
Speaker: Xinjian Zhu, PhD (the Children’s Hospital of Philadelphia)
Abstract: Epilepsy is a disease of recurrent seizures that can develop after brain insults. To prevent the morbidity and mortality associated with the epilepsy we need to better understand the molecular and cellular mechanisms that contribute to the development of epilepsy. Several lines of evidence suggest that cAMP response element-binding protein (CREB) might be involved in the development of epilepsy. In this study, the chemoconvulsant pilocarpine and kindling model were used to investigate the role of CREB in the development of epilepsy. Our results implicated that deficiency of CREB suppressed the development of epilepsy in the pilocarpine and the kindling model. Blocking CREB activity following a brain insult may suppress the development of epilepsy.
Snack and beverage will be served. For event details, future event announcement, or subscription to the discussion group, please visit www.newPSF.org.
Photos here by Xiaoyu.
